New Insights into the Alveolar Epithelium as a Driver of Acute Respiratory Distress Syndrome

New Insights into the Alveolar Epithelium as a Driver of Acute Respiratory Distress Syndrome

Blog Article

The alveolar epithelium serves as a barrier between the body Rolling Trays and the external environment.To maintain efficient gas exchange, the alveolar epithelium has evolved to withstand and rapidly respond to an assortment of inhaled, injury-inducing stimuli.However, alveolar damage can lead to loss of alveolar fluid barrier function and exuberant, non-resolving inflammation that manifests clinically as acute respiratory distress syndrome (ARDS).This review discusses recent discoveries related to mechanisms of alveolar homeostasis, injury, repair, and regeneration, with a contemporary emphasis on virus-induced lung injury.

In addition, we address new insights into how bicycles the alveolar epithelium coordinates injury-induced lung inflammation and review maladaptive lung responses to alveolar damage that drive ARDS and pathologic lung remodeling.